Long-term stress or chronic stress can lead to some severe physical and psychological damage to your body. It can even develop into some long-term disorders like depression or an anxiety disorder. Chronic stress can lead to heart disease or unstable angina. Angina leads to pain in your chest brought which is caused by insufficient supply of oxygen. It can even trigger a heart attack. If you are under an enormous amount of stress it can lead to high blood pressure problems. If you have induced high blood pressure, then you are increasing your risk for a stroke.